Internal Workings of the Mind is a quest assigned by Isham Seely. After Joe has found more insulin and become closer to Alice, Isham will tell Joe he needs to talk to him. They talk about Alice and his intentions with her. The conversation then shifts and Isham starts talking about the last time he saw Charley Parkhurst. Joe is then given the quest to check out the area south of Sienna.
While Searching the roads south of Sienna, Joe and Isham fight their way through looters and infected wearing hazmat suits. Eventually they find Humvees with supplies and the Neural Imaging System. Joe becomes quite excited finding a tool that will help him manipulate people, while Isham tells Joe to go to hell.